1/30/24, 12:44 AM Mini-Essay on Bruton Agammaglobulinemia Mini-Essay on Bruton Agammaglobulinemia Description Cells communicate by generating, transmitting, and receiving chemical signals. Signal transduction pathways link signal reception with cellular response. B lymphocytes express specific receptors, the B- cell antigen receptor (BCR), that recognize antigens. A defect in Bruton's tyrosine kinase (BTK) causes a defective maturation of B-cells leading impaired signaling from pre-B-cell receptor. Instructions Write a Mini essay on Bruton Agammaglobulinemia. The development of B cells proceeds through several stages. Describe the stages of B cell development, and the checkpoints associated with the stages of development. What is Bruton's tyrosine kinase (BTK) and why is its function during B cell development very important ? What is the the Pre-B Cell receptor and how can impaired signaling from the Pre-B Cell receptor produce such a severe impairment of the antibody immune response? Briefly touch on the genetics of this disease. Describe the symptoms of this agammaglobulinemia, the pathogenesis of the disease, the diagnosis, treatment and prognosis of the disease. Explain why most infections are due mainly to common extracellular bacterial pathogens but patients can almost all the time, successfully fight intracellular infections, such as those caused by the common viral diseases of childhood. The mini essay is expected to be concise, and the topic covered in a focused, thorough and accurate manner. It should be at least 700 words long. Your essay must include proper heading at the top. Your essay should begin with a clear introduction and include either a single, or two shorter body paragraphs, as well as a concluding paragraph. Please submit as a Word doc (attach the file). Please include the citations you use for this essay. Expectations See attached rubric. Please view the rubric before you begin the assignment to better understand how to successfully complete. 1/4 1/30/24, 12:44 AM Bruton Agammaglobulinemia Mini-Essay y on Bruton Agammaglobulinemia 2/4 1/30/24, 12:44 AM Correct format Submits correct format. At least 600 words in length. Word doc The stages of B cell development Describes the stages of B cell development and the checkpoints Criteria Bruton's tyrosine kinase Bruton's tyrosine kinase function during B cell development Pre-B Cell receptor Describes the Pre-B Cell receptor Signaling through Pre-B Cell receptor Explains how impaired signaling from the Pre-B Cell receptor produces severe impairment of the antibody immune response Genetics of the disease Describes the genetics of the disease Symptoms Describes symptoms Pathogenesis Describes the pathogenesis of the disease. The diagnosis Explains how the disease is diagnosed Treatment Describes the treatment of the disease. Ratings 1.5 to >0.0 pts Full Marks 3 to >0.0 pts Full Marks 3 to >0.0 pts Full Marks 3 pts Full Marks 2 to >0.0 pts Full Marks 1 pts Full Marks 3 pts Full Marks 3 pts Full Marks 3 pts Full Marks 2 pts Full Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks Pts 1.5 pts 3 pts 3 pts 3 pts 2 pts 1 pts 3 pts 3 pts 3 pts 2 pts 3/4 1/30/24, 12:44 AM Criteria Prognosis Describes the prognosis of the disease. Mini-Essay on Bruton Agammaglobulinemia Bacterial vs Viral susceptibility Explain why patients are more susceptible to common extracellular bacterial pathogens but generally can fight common intracellular infections, https://doane.instructure.com/courses/14644/assignments/205686?module_item_id=457986 Ratings 2.5 pts Full Marks 3 pts Full Marks 0 pts No Marks 0 pts No Marks Pts 2.5 pts 3 pts Total Points: 30 4/4