2/20/24, 5:45 AM Mini-Essay on System Lupus Erythematosus Mini-Essay on System Lupus Erythematosus • Points 30 Submitting a text entry box or a file upload Description Systemic lupus erythematosus (SLE), also known simply as lupus, is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. Instructions Write a mini-essay using Systemic Lupus Erythematosus (SLE) as a model disease to describe self- tolerance and failure in self-tolerance. Include how peripheral and central tolerance is established in B cells and T cells. You should also include the epidemiology, the pathogenesis of this disease, symptoms and signs, treatment and the prognosis. The mini essay is expected to be concise, and the topic covered in a focused, thorough and accurate manner. It should be at least 800 words in length. Your essay must be formatted with 1" margins, 1 1/2 line spacing, 12 point easy-to-read font;include a proper heading at the top. Your essay should begin with a clear introduction and must also have a concluding paragraph. Please submit as a Word doc (attach the file). Expectations See rubric. Systemic lupus erythematosus (SLE) https://doane.instructure.com/courses/14644/assignments/205689?module_item_id=458005 1/2 2/20/24, 5:45 AM Format Minimum 800 words in length Self tolerance Explain Self tolerance Criteria Central tolerance Describe the mechanisms of central tolerance in T and B cells Peripheral tolerance Describe the mechanisms of peripheral tolerance in T and B cells Symptoms and signs Describe the symptoms and signs Mini-Essay on System Lupus Erythematosus Pathogenesis and epidemiology Describe the epidemiology, and pathogenesis (the manner of development of the disease) of SLE. Be detailed and thorough, ensuring you describe the formation of immune complexes and what the consequence is of that. Treatment Describe the treatment of SLE Prognosis What is the likely course or outcome of SLE https://doane.instructure.com/courses/14644/assignments/205689?module_item_id=458005 Ratings 2 to >0.0 pts Full Marks 2 to >0.0 pts Full Marks 5 to >0.0 pts Full Marks 5 to >0.0 pts Full Marks 6 to >0.0 pts Full Marks 4 to >0.0 pts Full Marks 3 to >0.0 pts Full Marks 3 pts Full Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks Pts 2 pts 2 pts 5 pts 5 pts 6 pts 4 pts 3 pts 0 pts No Marks 3 pts Total Points: 30 2/2