Code Markdown Run All Ex Clear All Outputs Outline Select Kernel Project A.1: Pharmacokinetics - Drug concentration dynamics Background Pharmacokinetics (PK) is the study of how the body interacts with administered substances for the entire duration of exposure (medications for the sake of this article). This is closely related to but distinctly different from pharmacodynamics, which examines the drug's effect on the body more closely. This field generally examines these four main parameters: absorption, distribution, metabolism, and excretion (ADME). Possessing an understanding of these processes allows practitioners the flexibility to prescribe and administer medications that will provide the greatest benefit at the lowest risk and allow them to make adjustments as necessary, given the varied physiology and lifestyles of patients. Source In this project you will explore the differential equations used to model Pharmacokinetics based on method of drug administration. • One compartment models: • Instantaneous input - Intravascular injection (single shot) • Zero order input - Intravascular infusion (IV over time) 。 First order input - Extravascular administration (digested pill) 。 Multiple Instantaneous input - Intravascular injection repeatedly (daily shot) • Multiple first order input - Extravascular administration repeatedly (daily digested pill) • Two compartment models:

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