Description Major Histocompatibility Complex is a cluster of genes found in on Chromosome 6 in humans. The product of these clusters of genes play a role in discriminating self/non-self, and

participate in both humoral and cell- mediated immunity by acting as antigen presenting structures. Instructions Describe how the term Major Histocompatibility Complex was derived. Explain what is meant by MHC restriction. Class I and class II MHC molecules are membrane-bound glycoproteins that are closely related in both structure and function, yet have dissimilar pathways of assembly and delivery to the cell surface that translate to the different functions of class I and class II molecules and their associated molecules. Describe the different polypeptide chains that comprise the MHC Class 1 and 11 molecules; also describe how the peptides bound to each class differ from each other. Explain how the cleft or groove for peptide binding is formed formed on each class of molecule. Describe which cells can express and present antigen on MHC class I and/ or MHC class II molecules. The mode of antigen entry into cells and the site of antigen processing determine whether antigenic peptides associate with class I MHC molecules or with class II molecules. Explain what exogenous and endogenous antigens are. Describe both endogenous pathway of antigen processing and presentation, and the exogenous pathway of antigen processing and presentation and how the peptide is then presented on the cell surface. What advantage would there be for the protection of our bodies to have at least two pathways for antigen processing and presentation? What types of infections/diseases do MHC class I or MHC class II presentation pathways tend to protect against? The mini essay is expected to be concise, and the topic covered in a focused, thorough and accurate manner. It should be at least 600 words in length. Your essay must be formatted with 1" margins, 1 1/2 line spacing, 12 point easy-to-read font; include a proper heading at the top. Your essay should begin with a clear introduction and must also have a concluding paragraph. Please submit as a Word doc (attach the file). Expectations Criteria Role of MHC Complex This criterion is linked to a Learning OutcomeCorrect format Submits correct format. At least 600 words in length. Word doc This criterion is linked to a Learning OutcomeMajor Histocompatibility Complex nomenclature How was the term was derived This criterion is linked to a Learning OutcomeMHC restriction Explains MHC restriction This criterion is linked to a Learning OutcomeMHC Class 1 structure Describes different polypeptide chains that comprise the MHC Class 1 This criterion is linked to a Learning OutcomeMHC Class 11 structure Describes different polypeptide chains that comprise the MHC Class 11 This criterion is linked to a Learning OutcomeMHC Class 1 peptide binding groove Explains how the cleft or groove for peptide binding is formed formed MHC Class 1 This criterion is linked to a Learning OutcomeMHC Class 11 peptide binding groove Explains how the cleft or groove for peptide binding is formed formed MHC Class 11 This criterion is linked to a Learning OutcomeMHC Class 1 bound antigenic peptide Describe details of the antigenic peptide bound by MHC Class 1 This criterion is linked to a Learning OutcomeMHC Class 11 bound antigenic peptide Describe details of the antigenic peptide bound by MHC Class 11 This criterion is linked to a Learning OutcomeMHC Class 1 cells Describes which cells express and present antigens on MHC class I This criterion is linked to a Learning OutcomeMHC Class 11 cells Describes which cells express and present antigens on MHC class 11 This criterion is linked to a Learning OutcomeExogenous antigen Explain what exogenous antigens are and how they are processed This criterion is linked to a Learning Outcome Endogenous antigen Explain what endogenous antigens are and how they are processed Ratings 1.5 pts Full Marks 1 pts Full Marks 2 to >0.0 pts Full Marks 2 to >0.0 pts Full Marks 2 >0.0 pts Full Marks 2 to >0.0 pts Full Marks 2 to >0.0 pts Full Marks 2 to >0.0 pts Full Marks 2 to >0.0 pts Full Marks 1.25 to >0.0 pts Full Marks 1.25 to >0.0 pts Full Marks 3 to >0.0 pts Full Marks 3 to >0.0 pts Full Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks Pts 1.5 pts 1 pts 2 pts 2 pts 2 pts 2 pts 2 pts 2 pts 2 pts 1.25 pts 1.25 pts 3 pts 3 pts See attached rubric. Rubric Role of MHC Complex PreviousNext