Instruction: Give concise answers to the questions below. Consult any references you may need. Your answer for each question should be no more than two pages, excluding references. 1) Compare and contrast antibodies produced by hybridoma technology and by phage display technology with respect to their a) immunogenicity b) examples of approved usage 2) Explain the importance of each structural component of an antibody-drug conjugate (ADC). Discuss one to two strategies that could enhance the delivery of ADC to cancer cells. 3) Discuss the potential advantages and disadvantages of CRISPR technology as therapeutics in humans. 4) Compare and contrast aptamers and siRNAs with respect to their a) intended targets, b) mechanism of action, and c) use as potential therapeutic agents. 5) Discuss the potential advantages and disadvantages of aptamers as therapeutics vs. conventional drugs.

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