Journal Club PHRM 535 Pharmacy Practice Lab V In PHRM 535 you will be expected to, in teams, lead one journal club discussion and participate in a second journal club discussion.

The student team leading journal club will be responsible for preparing a handout, presenting the article, guiding the discussion, and evaluating a related patient case. The student team participating in journal club will be responsible for paying attention, asking questions, and evaluating the journal club leaders. All students (leaders and participants) must review the assigned article prior to class. Teams leading journal club will be allotted 30 minutes to provide an overview of the study, their interpretation of results, and their critique of the study. It is suggested to allow 10 to 15 minutes for the study overview, 10 to 15 minutes for the critique, and 5 to 10 minutes for questions. The individual who will lead each section (e.g., introduction, methods, statistics, results) will be decided at random at the time of the presentation; as such, it will benefit the entire team if all members are familiar with all aspects of the article. Students may be called on to participate once or more than once. Each team will be evaluated by a course instructor and another student team (see provided evaluation forms). Teams that do not earn 70% of the content points will repeat the activity. Teams that do not prepare an acceptable handout (considering both content and professional presentation) will re-do that portion of the assignment at the discretion of the course instructor and course coordinator. You will be working with your selected team for journal club. The following table describes your assigned articles for when your team are the journal club leaders and when your team are the journal club participants: Points will be earned for the following activities: 1. Leading journal club 2. Evaluating another team's journal club 40 points 10 points/nEvaluation: Please see the separately attached rubrics that will be completed by faculty and participating students. Participating students should note that portions of the evaluation must be completed prior to lab. Students evaluating another journal club team will be required to complete Part 1 of the evaluation on paper prior to lab, and then submit a paper copy with their complete evaluation containing Part 1 and Part 2 by the end of lab. Instructions for using the attached template: 1. The journal club handout should provide an OVERVIEW of key information from the article - it should not rewrite the entire paper. For PHRM 535, the length limit for journal club handouts is 4 pages (i.e., 2 pages front and back which includes the references). You will use this handout to verbally present to the group. (No PowerPoints.) 2. All requested information should be included; however, do not feel like you need to discuss every point in the handout during your discussion. For example, you may chose not to address the location of the study in detail unless an audience participant asks about it. 3. The journal club critique is organized using the approach from PHRM 420; however, you may feel free to reorganize the critique section as necessary. 4. The prompts listed in the critique section are not exhaustive; similarly, each issue may not apply to each study. Citation Location Funding OVERVIEW ▪ Provide the complete article citation using AMA format. ▪ Provide information regarding study sites including institution, state, and country, if applicable. ▪ Describe the funding source and the role they played in the study (e.g., provided medication, developed study, developed manuscript, approved manuscript). INTRODUCTION/nBackground Previous Trials Potential Impact Objectives Study Design Inclusion Criteria Exclusion Criteria Interventions Primary Endpoint Secondary Endpoints Safety Endpoints Statistical Analyses Enrollment INTRODUCTION ▪ Provide a concise overview of the pertinent drug(s), disease state(s), etc. that have bearing on the discussion. This should include information besides just what is provided in the article intro. ▪ Cite and briefly discuss two to three previous trials that have bearing on the primary article. Summarize key details of the results and indicate how these studies led to the one being reviewed in the current presentation. This should include information besides just what is provided in the article intro. ▪ Based on the authors' objectives, background information, and previous trials, describe the potential impact the results of this study could have on practice. ▪ Paraphrase the authors' stated objective for the study. METHODS Provide an overview of the following: Study type (e.g., case-control, clinical trial), phase of drug development (i.e., I, II, III, IV), randomization, control, blinding, etc. as applicable. ▪ List and discuss stated inclusion criteria; highlight key information. ▪ List and discuss stated exclusion criteria; highlight key information. List and discuss stated inclusion criteria; highlight key information. ▪ List and discuss stated exclusion criteria; highlight key information. ▪ Provide dosing, schedule, etc. for intervention, comparator, and monitoring. NOTE: This section does not apply to observational studies. ▪ List and discuss the primary endpoint. NOTE: For clinical trials, the primary endpoint is the endpoint used in the power calculation. If there is a discrepancy between the actual primary endpoint and the authors' described primary endpoint, this should be addressed. ▪ List the secondary endpoints; highlight key secondary endpoints. ▪ Describe the authors' adverse drug event monitoring plan and any other related safety endpoints. ▪ List and describe the statistical tests used; describe the power calculation; note the populations analyzed (e.g., intention to treat, per protocol, as treated). RESULTS Describe issues such as number of patients screened, number/percentage of patients randomized, number/percentage of patients who received the intervention vs. control; include an overview of adherence, attrition, and other related considerations. Baseline Characteristics ▪ List and describe the results for base line characteristics that are key to understanding and applying the study; this section should provide the audience with a clear picture of who was enrolled in the study. Differences between groups should be made clear.