Please write a 200-250 word reflection paragraph about the webinar given by Dr. Dina Schneidman-Duhovny, titled "Integrative Structural Modelling in the Age of Deep Learning". Give your opinions and discuss it./n PowerPoint Slide Show - [Kadir Has_May2022] Epitopes mapping of SARS-CoV-2 neutralizing nanobodies by integrative modeling with cross-links Major Challenges: 1. Accurate modeling of nanobody/antibody loops 2. Accurate antibody-antigen docking 3. High-throughput Collaboration with Shi lab, Xiang et al. Science 2020, Cell Systems 2021 Talking: Dina Schneidman PowerPoint Slide Show - [Kadir Has_May2022] Talking: Antibody vs. Nanobody (single domain antibody camelids including Llamas, alpacas and camels have a dual-immunoglobulin system antibody camelid heavy chain antibody nanobody T Lenovo heavy chain light chain o nanobodies can reach comparable binding affinities despite smaller size (CDR3 is longer) o small - easy to produce and deliver o highly stable and soluble o easily bioengineered 。 better tissue penetration o high sequence similarity to human IgG Lab Merav Braitbard Jerome Tubiana Tomer Cohen Matan Halfon Edan Patt Shon Cohen Thanks! Docking Haim Wolfson Ruth Nussinov Yuval Inbar RSC Nir Kalisman Roger Kornberg Yahli Lorch TEL AVIV UNIVERSITY Nsp2 Nir Kalisman Michal Linial ContactNet Raanan Fattal BSF SARS-CoV-2 nanobodies Yufei Xiang Zhe Sang Sham Nambulli Zhengyun Xiao Heng Liu Paul Duprex Cheng Zhang Yi Shi UNIVER Talking: Dina Schneidman TY OF 5-1 PITT VERITAS 787 VIRTUS BUR URGH PowerPoint Slide Show - [KadirHas_May2022] Talking: Dina Schneidman Addressing challenging protein-protein interactions with deep learning Lenovo • PowerPoint Slide Show - [Kadir Has_May2022] RSC puzzle with improved coverage Flexible proteins identified by cross-links: RSC2 - DNA binding Talking: Dina Schneidman 26 B

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