1. A drug molecule is being investigated for the chronic treatment of schizophrenia and will shortly enter human trials given the physicochemical properties below suggest the most appropriate route of

administration and a suitable dosage form fully justifying your answer Log P = 3.5 Melting point = 144°C Aqueous solubility = 20 mg/L (at 25°C) Volume of distribution 9.6-19.7 L/Kg Oral bioavailability = approx. 20% Extensive first pass metabolism Stable in aqueous solution