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1) The ethyl ester of naproxen can be synthesized in racemic form and treated under

special conditions so that the racemic compound converts entirely to a single

enantiomer.

insa

a) Describe a set of reaction conditions that might allow this to happen. You may not use

any chiral reagents.

b) If you used the method that I had in mind, you had no control over which enantiomer

would be obtained. However, only the enantiomer above is biologically active. How

could you modify your experiment to ensure that the desired enantiomer is obtained?

Fig: 1