(a) Atropine is described as a competitive, reversible antagonist at muscarinic receptors for acetylcholine. Which ONE of the following is an INCORRECT statement regarding atropine?(1 mark) a.Atropine binds at a different site on the muscarinic receptor from acetylcholine Atropine would be expected to display surmountable antagonism c. Atropine prevents muscarinic receptor activation by acetylcholine d. Atropine can dissociate from the muscarinic receptors e. Atropine binds the muscarinic receptors without producing a response on its own b) Atropine is metabolised by cytochrome P450 enzymes in the liver to multiple,pharmacologically inactive products. Which of the following statements about the pharmacokinetics of atropine is FALSE? (1 mark) a. Atropine is a pro-drug b. First pass metabolism would reduce atropine bioavailability c. The metabolic products of atropine would be excreted in the kidney d. Cytochrome P450 would add reactive centres to the atropine molecule e. Cytochrome P450 enzymes can catalyse more than one reaction with atropine as a substrate (c) Absorption of orally administered atropine happens in the gastrointestinal tract. Identify the two regions A and B on the diagram of GI anatomy below. Choose from the options in the box next to the diagram. (2 marks)

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