introduction this assignment aims to deepen your understanding of the
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Introduction
This assignment aims to deepen your understanding of the toxicological impacts of specific com-
pounds one may be exposed to in occupational and public health contexts. It is structured to
develop your research skills, enhance your critical thinking, and engage with scientific literature
and Artificial Intelligence (AI). You are required to use ChatGPT 3.5 (no other AI model may be
used) for initial research on one question, while the rest of the assignment must be based on in-
formation gathered from scholarly sources (e.g., academic journals and books) and written in your
own words. Note: you may have to sign up for ChatGPT, but it is free and you do not need to pay.
Please read all the following instructions carefully.
Students are assigned different toxicants based on the first letter of their LAST name:
• A-F: Formaldehyde
. G-L: Benzene
M-R: Asbestos
. S-Z: Glyphosate
General Instructions
For Questions 1-4, do not use ChatGPT. Base your answers on scholarly articles, books,
and other reputable sources. There is no limit to the number of sources you may consult,
but be careful and consider if you have enough.
• For Question 5, use ChatGPT 3.5 for preliminary research. Compare its response with
the information you found in academic sources, critically evaluating the information. The
output does not count towards your word count.
• Your responses should not exceed an overall total of 1000 words for the entire assignment
(break up this number as you wish amongst the questions).
• Include in-text citations and a bibliography in APA citation style (don't forget to cite the
use of ChatGPT as well!). In text citations do not count towards the word count. 1 Formaldehyde Toxicology
1.1
Questions
1. Overview of Formaldehyde: Research and describe formaldehyde, focusing on its common
sources of exposure in occupational and public health settings.
2. ADME Principles: Explain the Absorption, Distribution, Metabolism, and Excretion
(ADME) of formaldehyde in the human body. Highlight the key factors that influence its
toxicokinetics
3. Mechanism of Toxicity: Detail the mechanism by which formaldehyde exerts toxic effects
on the human body.
4. Case Study Analysis: Utilize academic literature to analyze a case study where formalde-
hyde exposure led to significant health issues.
5. Chat GPT Comparison: Use ChatGPT to obtain information about formaldehyde's health
effects by using the query Can you provide an overview of the health effects and ADME
principles related to formaldehyde exposure in 100 words? Run this once only and provide
the output from Chat GPT. Compare this with what you have found from academic sources,
discussing any discrepancies or confirmations.
2 Benzene Toxicology
2.1 Questions
1. Overview of Benzene: Using scholarly literature, discuss the properties of benzene and
its common uses that lead to occupational or public health exposures.
2. ADME Principles: Explain the Absorption, Distribution, Metabolism, and Excretion
(ADME) of benzene in the human body. Highlight the key factors that influence its toxi-
cokinetics
3. Mechanism of Toxicity: Explain how benzene affects human health, including its carcino-
genic potential.
4. Case Study Analysis: Examine a case from academic sources where benzene exposure
caused health issues. Cabe Buddy T
hyde exposure led to significant health issues.
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2 Benzene Toxicology
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5. ChatGPT Comparison: Use ChatGPT to obtain information about formaldehyde's health
effects by using the query Can you provide an overview of the health effects and ADME
principles related to formaldehyde exposure in 100 words? Run this once only and provide
the output from Chat GPT. Compare this with what you have found from academic sources,
discussing any discrepancies or confirmations.
2.1 Questions
1. Overview of Benzene: Using scholarly literature, discuss the properties of benzene and
its common uses that lead to occupational or public health exposures.
2. ADME Principles: Explain the Absorption, Distribution, Metabolism, and Excretion
(ADME) of benzene in the human body. Highlight the key factors that influence its toxi-
cokinetics
3. Mechanism of Toxicity: Explain how benzene affects human health, including its carcino-
genic potential.
4. Case Study Analysis: Examine a case from academic sources where benzene exposure
caused health issues.
5. Chat GPT Comparison: Use ChatGPT to obtain information about benzene's health
effects by using the query Can you provide an overview of the health effects and ADME
principles related to benzene exposure in 100 words? Run this once only and provide the
output from ChatGPT. Compare this with what you have found from academic sources,
discussing any discrepancies or confirmations. Submission Guidelines
• Submit your assignment as a single .PDF document, clearly indicating the toxicant
based on your last name. Include question numbers for organization; a title page is not
required.
• Ensure your work is clearly written, well-organized, and demonstrates a comprehensive un-
derstanding of the toxicological effects of the investigated compound.
• The critical analysis in Question 5, comparing ChatGPT's information with scholarly sources,
will demonstrate your ability to discern credible information and synthesize knowledge - and
demonstrate why AI is not always right!
Marking Rubric
There are a total of 70 points available based on the following criteria:
Criteria
1. Understanding of the Topic (20 Points): Demonstrates a thorough knowledge of the
chosen chemical, including exposure sources and toxicity mechanisms.
2. Analysis and Critical Thinking (20 Points): Effectively analyzes case studies and
evaluates ChatGPT's insights against academic sources.
3. Use of Academic Sources (10 Points): Uses scholarly sources appropriately, with accu-
rate citatio and bibliography according to the specified style.
4. Quality of Writing (10 Points): Presents information clearly and coherently, with proper
grammar and spelling. Please do not use bullet points.
5. Adherence to Guidelines (10 Points): Complies with all instructions, including word
count, correct chemical selection, and submission format.
Important Note
Selecting the incorrect chemical based on your last name results in a score of 0. It's M my.torontomu | my.torontomu X M Assignments - OHS322 011/0 X
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• Ensure your work is clearly written, well-organized, and demonstrates a comprehensive un-
derstanding of the toxicological effects of the investigated compound.
• The critical analysis in Question 5, comparing ChatGPT's information with scholarly sources,
will demonstrate your ability to discern credible information and synthesize knowledge - and
demonstrate why AI is not always right!
Marking Rubric
There are a total of 70 points available based on the following criteria:
Criteria
1. Understanding of the Topic (20 Points): Demonstrates a thorough knowledge of the
chosen chemical, including exposure sources and toxicity mechanisms.
2. Analysis and Critical Thinking (20 Points): Effectively analyzes case studies and
evaluates Chat GPT's insights against academic sources.
3. Use of Academic Sources (10 Points): Uses scholarly sources appropriately, with accu-
rate citations and bibliography according to the specified style.
4. Quality of Writing (10 Points): Presents information clearly and coherently, with proper
grammar and spelling. Please do not use bullet points.
5. Adherence to Guidelines (10 Points): Complies with all instructions, including word
count, correct chemical selection, and submission format.
Important Note
Selecting the incorrect chemical based on your last name results in a score of 0. It's
crucial to follow this guideline to ensure your work is evaluated. All assignments will
be scanned through Turnitin, which checks your work for originality, AI use, and helps ensure
academic integrity.
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