Q4. The total clearance (CL) and hepatic clearance (CL) of amlodipine are 49 L/h and 44 L/ h, respectively. Calculate the renal clearance (CLR) of this drug. What assumption was made

when calculating CLR? Based on clearance data provided, what is the main elimination mechanism for amlodipine? Alaa Q5.The hepatic extraction ratio of amlodipine is 0.5. Would you expect changes in (i) the fraction unbound in plasma of amlodipine, and (ii) hepatic blood flow to affect the CL of amlodipine? Explain your reasoning. How would your answer be different if the hepatic extraction ratio was 0.9? Alaa