Description In biology, the structure of different molecules correlates with its function. All antibodies share some common structural features, that correlate with the function of an antibody. Instructions Create a 3-4

minute (minimum) video using screencast-o-matic Links to an external site. of a model you have made from play dough, or clay, or any kitchen items really, and describe the following structural features, and the role the structures play in the basic functioning of the antibody. Please do not submit a diagram in lieu of a model; creating a model will enable you to actually study the details of the structural features of an antibody. The structure of immunoglobulins incorporates several features essential for their participation in the immune response and these structural features will need to correlate with the function of the the antibody. Before you describe the actual structure of your model, begin your presentation by explaining what the immunoglobulin superfamily is, which biological molecules belong to this, and the structural similarities that classify the members to this family. In your antibody model, please point out and describe ALL of the fundamental features (listed below), and the significance of this particular component to the specific function of the antibody. o The heavy chain (include how many domains there are in a heavy chain, number of amino acids etc) o The light chain (include how many domains there are in the light chain, number of amino acids etc) o o The paratope The hinge: what is this region of the antibody? Why is this region essential to the function of the antibody? The disulfide bonds o o The complementarity-determining region O Does the Fab fragment consist only of the variable region of the antibody? What about the Fc fragment? O/n*How do the secreted antibodies differ from the B-cell antigen receptor found on the surface of a B cell? Why is this difference essential to forming a receptor as opposed to a secreted antibody? ** Finish your presentation by listing the functions/actions of antibodies. These are different ways you can submit your video. A. submitted as mp4 files directly in Canvas or link to screencast-o-matic. B. an embedded video or C. an accessible link in YouTube or D. a shareable Google Drive folder. Please do not submit.Mov or .webm video files, as I cannot open them.