PHA223 Rapid Review 2023-2024 Guidance Notes & Generic Marking Scheme Topic:-Development of Nanomedicine Strategies to Target Coronavirus Article link :- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457919/ Requirements - 3000 words (without reference) - you can use a maximum of 6 references - make sure that u including every single point - highlighting the small topic that in each section Structure of your assignment The required length of this assignment is 3000 words (+/- 10%), excluding references. A penalty will be applied if the word count falls below or exceeds this limit in accordance with standard university procedures. No special adjustments on words counts will be made for figures, tables, or flow charts. The word count will be adjudicated using Microsoft Word. Guidance on Assignment Structure 1. INTRODUCTION You must outline your question and the aims of your literature search. This section needs to set the scene of your topic by including relevant background information surrounding key concepts of your topic. In your introduction, you will give definitions and provide sufficient information for the reader to understand your topic and what you will be searching for in the literature. Your introduction should be structured in a way so that a reader understands exactly what your literature search will focus on. 2. METHODOLOGY In this section, you need to clearly explain your search strategy. Everything you do to identify selected articles for discussion must be clearly stated in this section. This includes outlining which key words were used, which databases were searched, when the databases were searched and any search criteria/filters that were applied. If a reader was to screen your methodology, they should arrive at the same articles as you did if you outlined your processes effectively. You must also include details of your inclusion/exclusion criteria that you apply when screening each article. You must also include a PRISMA flow diagram outlining your process of selecting articles and at what stages you applied your inclusion/exclusion criteria. To support you with your methodology and identification of suitable articles, please refer to the Rapid Review lecture and the online recording provided by the library services team. 3. RESULTS & CRITICAL APPRAISAL You must present your literature findings to the reader and therefore, the evidence for the proposition or therapeutic intervention you have outlined in your topic. This must include an effective critique of the identified literature with associated interpretation and link back to your topic. You will be expected to analyse your selected articles for the strengths and weaknesses of their conclusions based upon the quality and appropriateness of their studies. It will be beneficial to create a “summary table" of your literature findings which outlines some key information relating to each article included. 4. DISCUSSION & CONCLUSION You will need to finish your report by summarizing your findings and explaining relevance into practice/science. You will need to make clear concluding statements as to whether your literature findings have a clear outcome and ensure that your conclusion directly relates back to your topic. 5. REFERENCES Full in text citations are essential in addition to a full, accompanying bibliography. Either Harvard or Vancouver referencing style will be permitted. This will not form aprt of your word count. Oral Viva In addition addition to the written work you will submit, you will be asked to present yourself for an oral discussion with your tutor, probably after the Easter break. The conversation will be related to the dissertation that you have submitted and can be expected to last approximately 20 minutes. The exact dates and times that you must attend this meeting will be announced later in the term. The assignment comprises 30% of the available marks for PHA223. Within this 30%, 90% of the marks are attributed to the written work and 10% of the available marks are available via the oral defence. As the member of staff you will be holding your discussion with will want to read your written report before talking to you, it is imperative that you hand in your work by the deadline as stated above. Failure to hand in your work on time will therefore also have a negative impact on your ability to perform well in the oral discussion component of this assignment as well as the written component. Any problems or questions, please contact Alex To support you in the development of your review, I have created a very brief checklist of the key components I expect your review to contain (please see next page). 3 Appendix 1 – PRISMA Guides - he following link will support you in writing your report. This is a direct link to the PRISMA diagram which must be included within your methodology section. PRISMA 2020 flow diagram new SRS v1.docx (live.com) The following link directs you to the PRISMA checklist. This will support you in developing your own reviews. A checklist for use in your report has also been produced for you which links to the PRIMSA checklist. Microsoft Word - PRISMA 2009 Checklist.doc (prisma-statement.org) Biology of the virus Surface proteine Structure of proteine SRNA,DNA, transmetion (incoded genes) why we don't use the proteine it self in the body? Bread about the vaccien, applications ☹important of nanomedicien esearch for other therapates drugs for (could) example => clorophein - not very effectiev) Eviruse behaffier inside the body (particelse) ∞other uses of nanomedicen Res peratory system Title Spike Serves protein Included Appendix 2 - Checklist Section Introduction Background Aim Methodology Search terms and database Eligibility Criteria Search Strategy Data Collection Article Information Bias Assessment Synthesis methods Study selection Results & Discussion Summary table Synthesis of results Summary of findings Conclusion Conclusion Sumerias Checklist item Title clearly stated. Outline definitions and key concepts relating to your topic. State the aim of the review (chart) Draw Specify all databases, search engines (and all other sources) used to identify your articles. Date ranges of searches should be included. Clearly state the inclusion and exclusion criteria used to select your articles State all filters applied during your literature searches State how you decided whether a study met inclusion criteria and how you screened each article to determine this. Provide details of outcomes for which data was sought (for example: article types, participant characteristics, intended outcomes) Provide details on how you reduced risk of bias within your own searches Outline how you will document your findings Include the PRISMA flow diagram Brief summary of each article identified for inclusion (optional) Critically appraise the findings from each article and integrate findings into core themes. Ensure that all interpretations are linked and discussed in relation to your research topic. Strengths and weaknesses of the articles should be highlighted and discussed to provide context into your discussion. Assessment of bias within your articles should also be included. Where necessary, discussions of statistical significance should also be made. Discuss the findings in relation to what is already known about your topic. Do they support what is already known, do they add new information, or do they disagree with previously outlined facts? General overview of findings and implications linked to your topic. Ensure this is clear, concise, and not a repetition of previously discussed findings. Outline whether any future research is required as a result of your findings or if there is a clear conclusion from your gathered information. References References Full list of bibliography references linked to in text citations. Use Harvard or Vancouver referencing style Draft 22/2 Ginars onmeron march