Question

14. You are studying a new kinase inhibitor called Destanib. Destanib binds to its desired target, Csk

kinase, with a KD of 1 nM. However, it also binds to another kinase (Src) with a KD of 10 µM. At what

approximate concentration of destanib would Csk kinase, and not Src kinase, be almost completely

bound (>90%) by inhibitor? Please show how you came to your answer by using concepts that we

discussed in lecture. (6 pts)

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