2/6/24, 7:39 PM Inflammatory Story to Grandma Inflammatory Story to Grandma Start Assignment Description When the outer barriers of innate immunity are damaged, the resulting innate responses to infection or

tissue injury can induce a complex cascade of events known as the inflammatory response. Inflammation may be acute or chronic, contributing to conditions such as arthritis, inflammatory bowel disease, cardiovascular disease, and Type 2 diabetes. Instructions Imagine you are helping your Grandmother prepare for the Thanksgiving meal and she asks you what you are studying. You have just finished studying about inflammation in your Immunology textbook and you find it fascinating. How would you describe the inflammatory response to your 85 year old Grandmother at Thanksgiving? Remember, your Grandmother does not have the same prior knowledge that you do in this subject matter, so you will need to explain it in a way that will resonate with her. Create a 3 minute video using screencast-o-matic (https://screencast-o-matic.com/)_and describe how inflammation is initiated, the steps of initiation, the recruitment of the various cells and what their role is in this series of events, the hallmarks of an inflammatory response, how key cytokines can have a systemic effect, how inflammation is resolved or if not, how it persists, how the innate and inflammatory responses may be regulated, and how inflammation can be beneficial or harmful to the host. These are different ways you can submit your video. 1. submitted as mp4 files directly in Canvas or link to screencast-o-matic. 2. an embedded video or 3. an accessible link to the video you have uploaded in YouTube or 4. an accessible link to the video you have uploaded in a shareable Google Drive folder. Please do not submit .Mov or .webm video files, as I cannot open them. This video can be just of you presenting, but you are welcome to incorporate images as well. I don't want to limit your creativity! :) 1/3 2/6/24, 7:39 PM Expectations See attached rubric. Inflammatory Story to Grandma Please review the rubric before you begin the assignment to better understand how to do well. Although this rubric has been used to assess written pieces, this rubric is also well-suited to guide you in an oral presentation. Some Rubric (2) 2/3 2/6/24, 7:39 PM Criteria Correct Format This must be a video, and not a PowerPoint Initiation Describe how inflammation is initiated, explaining the steps of initiation Inflammatory Story to Grandma Cells Describe the recruitment of the various cells involved and what their role is in this series of events. Hallmarks What are the hallmarks of an inflammatory response? Cytokines Explain what the key cytokines are, and how they can have a systemic effect even to localized inflammation. Resolution Explain how inflammation is resolved Regulation Describe how the innate and inflammatory responses may be regulated, Harm and benefits Explain how inflammation can be beneficial and also harmful to the host. Ratings 2 to >0.0 pts Full Marks 4 to >0.0 pts Full Marks 4 to >0.0 pts Full Marks 4 to >0.0 pts Full Marks 4 to >0.0 pts Full Marks 4 to >0.0 pts Full Marks 4 to >0.0 pts Full Marks 4 to >0.0 pts Full Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks 0 pts No Marks pts No Marks 0 pts No Marks Pts 2 pts 4 pts 4 pts 4 pts 4 pts 4 pts 4 pts 4 pts Total Points: 30 3/3