2. A good rule of thumb for free energy at 25°C is that each -5.9 kJ/mol of free energy is worth a factor of

10 in the equilibrium constant. (3 pts [1+2])

a. Estimate the equilibrium binding constant for the association of a receptor with a ligand with a

AG association of -41 kJ/mol./nb. Is this rule of thumb good at both room temperature and the physiological human body

temperature? How will you deduce the answer to this question?