Question

8. Benzocaine has been tested as an an aesthetic for inhibition of m1 muscarinic acetylcholine signalling. Using the data below, plot a graph and determine the IC50. 20 marks Concentration (M)

1 x 10-6 10 x 10-6 100 x 10-6 1000 x 10-6 10000 x 10-6 100000 x 10-6 % of control response 97 93 78 56 42 36

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