Question

A method was being developed for the analysis of thyroxine tablets. 10 replicate measurements were made on a reference tablet standard that has 5.00±0.08 mg simvastatin to the 95% confidence

limit. The results for the simvastatin reference are given below: Calculate the mean, bias, and recovery for the analysis. Calculate the standard deviation. This may be carried out in Excel. Use an appropriate statistical test to determine whether there is any evidence that the bias is statistically significant. Use an appropriate statistical test to determine whether there is any evidence that the bias is statistically significant. State the uncertainty in the reference tablet. Calculate the total uncertainty in the analysis. Calculate the expanded total uncertainty in the analysis. Use an appropriate statistical test to determine whether the value of 6.01 mg should be excluded.

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