This question is about analgesics. The structure below shows the NSAID indometacin, used for treating inflammation in conditions such as arthritis, 1. (a) Explain which of the 3 rings in

indometacin are aromatic. (4 marks) (b) Indometacin contains an amide group. Draw out the most common resonance form ofthe amide group and state the effect it has on the amide group's structure. (2 marks) 2. The NSAID ibuprofen is a lipophilic drug that has a volume of distribution of approximately10 Lin a healthy 70 kg individual. Define the term "volume of distribution" and explain why aVd of 10 L is consistent with a high level of plasma protein binding in the blood. (6 marks) 3. Some NSAIDS are particularly susceptible to hydrolysis. Describe, with the aid of a diagram,water vapour adsorption to a tablet surface and describe the consequences for the drugstability (6 marks) 4. Before a medicine such as indometacin is approved for use, it must receive a marketingauthorization (MA). The company applying for an MA must submit a dossier. What does thisdossier contain? (4 marks)