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Expert help when you need it- Q1:Q4. The total clearance (CL) and hepatic clearance (CL) of amlodipine are 49 L/h and 44 L/ h, respectively. Calculate the renal clearance (CLR) of this drug. What assumption was made when calculating CLR? Based on clearance data provided, what is the main elimination mechanism for amlodipine? Alaa Q5.The hepatic extraction ratio of amlodipine is 0.5. Would you expect changes in (i) the fraction unbound in plasma of amlodipine, and (ii) hepatic blood flow to affect the CL of amlodipine? Explain your reasoning. How would your answer be different if the hepatic extraction ratio was 0.9? AlaaSee Answer
- Q2:Loperamide 1. What is the loperamide drug used for? 2. Why was it chosen? 3. When it is found 4. Properties of the API 5. Pka, PH and partition coefficient 6. Physical appearance Hp, BP and solubility 7. Why this specific formulationSee Answer
- Q3:18F-Fluoroestradiol PET-Imaging in Cancer-Clinical evaluation Describe the hypothesis of the clinical trial. What phase? Dosimetry? Proof of concept? Proof-of-pharmacology? • Describe the purpose of the trial in your report. • Describe the design. How many subjects? Scanning protocol? Inclusion criteria? Healthy volunteers or patients with a diagnosed condition? Control groups? What were the results and how should the results be interpreted? • How is the tracer used in the clinic today?See Answer
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