q8 5e83 10 points total 2 points each a based on this pdb does the com
Q8. 5E83 - (10 points total; 2 points each)
A. Based on this PDB, does the compound GBT440 stabilize the S or the R state?/nB. Draw an arrow pushing mechanism for the reaction between GBT440 and the alpha subunit
residue amine group.
% O₂ Saturation
GBT440 Log [M]
120/nC. Based on this experiment, what state does GBT440 stabilize?
D. Why is more GBT440 needed in the blood compared to purified protein?
- 600 μmol/l
- 300 μmol/l
- 0 μmol/l
45-40 -35 -30 -25
GBT440 [Log M
pO₂ (mm Hg)
100 120/nE. What could be a side effect of GBT440? Will you want this person to do much exercise when
taking this drug? Why?
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