Question

1. AZT was the first drug approved to treat HIV, the virus that causes AIDS. Explain why the six-membered ring of AZT is aromatic. Use molecular orbital theory as a basis.

2. Which labeled hydrogen is more acidic? (Hint: draw conjugate bases and explain the stabilityin terms of molecular orbital theory)

3. Hydroxychloroquine was in news as a potential treatment for coronavirus infection. (a)Explain why the ring system in Hydroxychloroquine is aromatic. (b) Determine the hybridization of each N atom. (c) In what type of orbital does the lone pair on each N atom reside?

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