Questions & Answers

Q10. Section 3-2: Systolic Blood Pressure: [6 marks] the systolic blood pressure of 30 randomly selected college students is Use grouped formulas to find approximations for mean, standard deviation, median, P30 and Q3. [1] Xg= [2] Sg5 [1] grouped median [1] P30 [1] Q3 =

Part 1: Can one argue that the relationship between the investigated exposure and outcome is causal? Explain your answer.

Part 2: How likely is the possibility that the results were a mere chance finding? Explain your answer.

Part 3: You were requested to again investigate the association between exposure to noise and hearing loss while also accounting for each worker's age, level of education, past history of a hearing ailment, and presence of comorbidity. What statistical analysis would provide an answer?

Part 4: After you have conducted the analysis in Part 3, the association between exposure to noise and hearing loss weakened and became statistically insignificant. Explain this finding.

In order to target a specific region of genomic DNA with CRISPR, researchers must include a guide RNA containing a 20-basepair (bp) long spacer sequence that matches the DNA sequence at the target site. One of the possible risks of genetic engineering methods is "off-target" editing, which occurs when a guide RNA matches a part of the genome other than the intended target site. (i) How many possible guide RNA sequences are there? (ii) Estimate probability that a single site in the human genome matches a random 20-bp spacer. State all your assumptions. (iii) After infection, HIV converts its RNA genome into DNA and inserts itself into the human genome. Imagine you have designed a 20-bp spacer to target and deactivate part of the HIV DNA sequence. Based on the previous answer, estimate the probability that this sequence will have at least one off-target match somewhere in the human X chromosome, which is 300 000 bp long (counting both strands). Note: when P is very small (close to 0), (1-P)^n is approximately equal to (1-nP). (iv) What would be the probability of an off-target site appearing somewhere in the entire human genome (6 billion pairs counting both strands)?

No Search results found!

Kindly submit your queries
we will make sure available to you as soon as possible.

Search Other Question