Abstract The main purpose of this experiment is to determine residence time and trials of kinetic analysis in the presence of the catalyst. this experimental research examined the hydrolysis of methyl acetate (MA) when the catalyst and cation exchange resin was present. Catalysts are chemicals that alter the direction of a reaction to change the rate at which it occurs by decreasing the activation energy, the energy threshold that must be overcome for a chemical reaction to take place, catalysts improve the efficiency of this process. Here, the kinetics of the catalysis was also investigated in addition to the material balance on the packed bed reactor. Mass transmission within the bed, as well as heat transfer and chemical reactions, must be considered in the design of packed-bed reactors. The report includes the determination of experimental controlling parameters of packed bed such as residence time, reaction rate, the reaction rate constant, activation energy, and Arrhenius rate constant. In the first week, the calculation for the residence time is completed, to determine the residence time C curve was plotted, and in the second week, the kinetic analysis is performed. The concentration of the methyl acetate was consumed determined by the acid-base titration method at the equivalence point the titration equivalence point is the point at which the titrant concentration is just right to neutralize the analyte solution. In an acid-base titration, the equivalence point occurs when moles of base equal moles of acid and the only components of the solution are salt and water, then reaction rate was determined, to calculate the Arrhenius constant and activation energy logarithms of k versus the inverse of temperature curve was plotted. Introduction The packed bed reactors are one of the essential chemical reactors employed in industries, and they contain solid catalyst particles to start the reaction. The solid catalyst particles engage with the reactants as they move through the reactors, a catalyst is a material that enhances the speed of reaction while it is remaining unaltered subsequently. A catalyst typically alters the rate of a reaction by encouraging a new chemical pathway​[1]​. To achieve reaction rates of realistic use, catalysts make it possible for reactions to happen significantly more efficiently and facilitate the use of lower temperature settings. They accomplish it just by providing a different route for the reaction to continue that has smaller activation energy ​[2]​. An incredible example of a catalytic process is the decomposition of methyl acetate, which does not occur under environmental conditions but does so when the proper catalysis is used. The following process entails the hydrolysis of methyl acetate by such an acid, which gives acetic acid and methanol (CH3OH) ​[3]​. CH3COOCH3+H2O↔CH3OH+CH3COOH CH3COOCH3+H2O↔CH3OH+CH3COOH The hydrolysis of methyl acetate (MA) in the presence of catalyst acid-charged cation exchange resin gives a solution of methanol and acetic acid in the process, which represents the addition of too much water to the MA solution (AA) ​[4]​. The configuration of the packing composite, which is controlled by the shape, size, and density of the constituent grains, has a significant impact on the design process of packed bed-oriented industrial applications ​[5]​. Packed bed reactors (PBRs) generally are solid catalyst-filled chemical reactors in that the reagents come into contact just as they pass through the reactor. catalyst is more expensive, it can be toxic and contaminants in a chemical reaction cause a catalyst to lose effectiveness these are the main disadvantage use of a catalyst. Ordinarily, the vertical flow direction is used when the packed bed reactor is in operating to prevent bed compression and facilitate gas bubble escape​[6]​. The design and development of packed bed-oriented unit processes are significantly influenced by the packing composite's configuration, which is determined by the morphology, size, and density of the component particles [6]. Reduced temperatures and rapid reaction rates during catalysis in catalyst reactors result in less production costs. By lowering the activation energy barrier separating reactants and products, a catalyst speeds up the manufacturing of molecules that otherwise would not be made quickly enough for implementable use ​[4]​. In a research facility's isothermal packed bed reactor, the catalyst was a very acidic cationic transfer resin utilized for lab work. 2.0 Safety and hazardous All actions and procedures taken to protect people’s life, health, and physical integrity are included in the paradigm of safety. Perhaps the key characteristic of designing is necessary throughout the board is safety. Each team member must wear the appropriate protection equipment (PPEs), which includes goggles, gloves, closed-toe shoes, and long pants. In our case experiment, it is essential to always wear gloves and goggles when dealing with methyl acetate, sodium hydroxide, and hydrochloric acid because MA Contact can burn and irritate the eyes, potentially resulting in irreversible damage. Methyl acetate may irritate the skin, resulting in symptoms including redness and itching. Kindly do not touch heated and hazardous material without gloves, hand gloves and goggles are used to avoid physical & chemical damage. The Safety Data Sheets (SDS) for any materials that were used explain the physical and chemical characteristics of the product. Hand gloves, eyewear, and any other protective suits should always be worn when handling heated or dangerous materials to prevent physical and chemical harm​[7]​. generally, stock HCl has a strength of about 37% or 12 mol/L, so to dilute HCL solution avoid the mistake of mixing strong HCl into water. Acid must be added to the water. If you approach it incorrectly, the initial droplets of water that mix with the concentrated acid would generate heat, evaporate, and may cause acid to spray out of the vessel and into you Stronger HCl is an extremely potent acid that will rapidly burn your epidermis upon contact, put on a lab coat, gloves, and glasses. ​[8]​. References ​​[1] “elements-of-chemical-reaction-engineering-6th-edition-by-h-scott-fogler-h-scott-fogler-z-liborg_compress”. ​[2] D. Murzin and T. Salmi, “Catalysis,” Catalytic Kinetics, pp. 27–72, 2005, DOI: 10.1016/B978-044451605-3/50002-2. ​[3] A. Çıtak and A. Kıvrak, “Determination of the Expression Rate of Ethyl Acetate Hydrolysis Reaction Depending on the Temperature,” Journal of the Institute of Science and Technology, pp. 382–388, Mar. 2019, DOI: 10.21597/jist.410336. ​[4] A. Skach, B. Rowland, B. James, T. Lake, J. Seaberg, and Y. Feng, “Standard Operating Procedures Packed-Bed Reactor for Methyl Acetate Hydrolysis.” ​[5] S. Afandizadeh and E. A. Foumeny, “Design of packed bed reactors: guides to catalyst shape, size, and loading selection,” Appl Therm Eng, vol. 21, no. 6, pp. 669–682, Apr. 2001, DOI: 10.1016/S1359-4311(00)00072-7. ​[6] M. Bechtold and S. Panke, “7.5 Reaction Engineering of Biotransformations,” Comprehensive Chirality, vol. 7, pp. 71–100, 2012, DOI: 10.1016/B978-0-08-095167-6.00705-9. ​[7] “Safety Data Sheets | Free SDS Database | Chemical Safety.” https://chemicalsafety.com/sds-search/ (accessed Oct. 05, 2022). ​[8] “Hydrochloric acid - OpenWetWare.” https://openwetware.org/wiki/Hydrochloric_acid (accessed Oct. 05, 2022). ​ ​