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5. (1 pt.) Two structures of aspirin, also known as acetyl salicylate, are shown below. Note that the structure on the left includes a weak acid functional group as it

would exist at a pH < 3. But at a higher pH, the acidic H is transferred to the hydroxide ions in water. The aspirin structure then is then a carboxylate with a negative charge as shown on the right. Non-polar compounds pass through membranes and enter the bloodstream better than polar ones. Given that the pH of the stomach is about 2 and the pH of the small intestine is about 8, where is there greater absorption of aspirin, the stomach or the small intestine? (Hint:charged molecules are polar.)

Fig: 1

Fig: 2

Fig: 3