A novel compound to treat sickle cell crisis is being developed that would act at 2 mg dose. It is currently formulated as a tablet of a total weight of 200 mg due to the need for excipients, and the total number of particles is determined at 200 000 per gram. Calculate all parameters as in question 8 and compare and contrast these two formulations. Suggest any alterations to these powders to alleviate the found problems.

Calculate the standard deviation, the coefficient of variation and the acceptable number of particles in the scale of scrutiny to ensure that we detect 1.5% as acceptable deviation.